Objective: Evaluation of the efficacy of methanolic extract of Hemidesmus indicus in urolithiasis induced by ethylene glycol on Wistar rats. Methods: Ethylene glycol (0.75%) in drinking water was fed to induce urolithiasis for 28 days on Wistar rats. The effect of oral administration of methanolic extract of Hemidesmus indicus root on calcium oxalate urolithiasis has been studied by analysis of different elements in urine, serum and kidney homogenate sample and is also compared with the effect of oral administration of Cystone as standard drug on Wistar rats. Results: Ethylene glycol feeding resulted in hyperoxaluria as well as increased renal excretion of calcium and phosphate. Supplementation with methanolic extract of Hemidesmus indicus root significantly reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. Conclusion: The results indicate that the root of Hemidesmus indicus is endowed with antiurolithiatic activity.
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